Science
Learn more about the science and technology behind our products!
Proteomics
Proteomics is the comprehensive study and analysis of the proteome, i.e. h. the totality of all proteins present in a cell, tissue, organism or specific biological system at a specific time. It deals with the identification, quantification, structure, function and interaction of proteins as well as their changes under different conditions.
By using advanced technologies such as mass spectrometry and bioinformatics tools, proteomics aims to gain a detailed understanding of the role of proteins in biological processes and diseases, thereby contributing significantly to the development of new diagnostic methods, therapies and understanding of disease mechanisms.
Why use proteomics?
Proteomics offers a kind of “live transmission” into the cell. With genetics we have so far only been able to make the blueprints visible. Proteomics now offers a new perspective. We can see whether proteins are changed again after translation, for example through phosphorylation or glycosylation. This means that we get a more detailed insight into what is going on in the cell. This allows researchers to better explore protein-protein interactions and thus better understand complex biological signaling pathways.
Proteomics is the next step towards more personalized medicine. In the future, research efforts may enable new disease biomarkers or therapeutic targets to be better identified. In addition, proteomics can help us better understand how drugs affect the body.
The research is still in its early stages, but there are already some very interesting studies. In this study, 36 people with various illnesses were examined before and after exercise. The analyzes were extremely comprehensive, ranging from blood tests to proteomic and genetic analyses. The researchers were able to determine that some proteins could be used as markers for later performance in endurance tests. They also found that people with insulin resistance respond differently to exercise. Some research is still needed before concrete treatment approaches can be derived from this, but the results so far are extremely exciting.
At MoleQlar Analytics, we use mass spectrometry to measure proteins from buccal swab samples
Mass spectrometry
Mass spectrometry is an analytical technique that measures the mass-to-charge ratio (m/z) of molecules, such as peptides, proteins, and drug metabolites, in a sample. In the diagnostic sector, mass spectrometry helps identify and quantify unknown and known compounds as well as evaluate their molecular structure and chemical composition, with better specificity and sensitivity than other methods. (Waddell Smith, 2013)
Revolution Diagnostic Test
While mass spectrometry is widely used in basic research, the technology has also become established for use in diagnostics over the last decade. As new generations of technologies come to market, clinical laboratories are using mass spectrometry for routine testing to improve molecular analysis, which can provide customers with faster test results compared to conventional assays.
MoleQlarAge
Did you know that biological age is a far more accurate indication of your health than the number of years you have lived?
Find out moreCheck out what we've investigated so far!
Our publications
Disabling leading and lagging strand histone transmission causes loss of parental histones and cell viability,
Sciences Advances, 2025
Kollenstart et. al
Acute multi-level response to defective de novo chromatin assembly in S-phase,
Mol. Cell, 2024
Dreyer J., et. al.
Backpain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells,
Frontiers, 2024
Burny C., et. al.
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity,
Nature Genetics, 2023,
Wenger A., et al.
DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network,
Mol Cell. 2023
Carraro M, et al.
A novel proteomics approach to epigenetic profiling of circulating nucleosomes.
Sci Rep 2021;11(1):7256.
Van den Ackerveken et. al.
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination.
Mol Cell. 2021;81(5):1084-99 e6.
Nakamura K, et al.
Endotoxinemia Accelerates Atherosclerosis via Electrostatic Charge-Mediated Monocyte Adhesion.
Circulation. 2020.
Schumski A, et al.
Histone Modifications in Stem Cell Development and Their Clinical Implications.
Stem Cell Reports. 2020.
Voelker-Albert M., et al.
Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes.
Cell Rep. 2020.
Alabert C, et al.
New Approaches for Absolute Quantification of Stable-Isotope-Labeled Peptide Standards for Targeted Proteomics based on a UV Active Tag.
Proteomics. 2020.
Schnatbaum K, et al.
Determining histone H4 acetylation patterns in human peripheral blood mononuclear cells using mass spectrometry.
Clinical Mass Spectrometry. 2019.
Bux EM, et al.
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells
Nature Cell Biology. 2025.
Voelker-Albert M., et al.
NASP modulates histone turnover to drive PARP inhibitor resistance
Nature. 2025
Voelker-Albert M., et al.
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial
Nature Medicine. 2025
Voelker-Albert M., et al.
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