Science
Find out more about science and technology behind our products!
Proteomics
Proteomics is the comprehensive study and analysis of the proteome, i.e. the entirety of all proteins that are present in a cell, a tissue, an organism or a certain biological system at a certain point in time. It deals with the identification, quantification, structure, function and interaction of proteins and with their changes under different conditions.
Through the use of advanced technologies such as mass spectrometry and bioinformatic tools, the proteomics aim to achieve a detailed understanding of the role of proteins in biological processes and diseases, and thus contributes significantly to the development of new diagnostic methods, therapies and the understanding of disease mechanisms.
Why use proteomics?
Proteomic offers a kind of " live broadcast " into the cell. So far we have only been able to make the blueprints visible with the genetics. Proteomic now offers a new perspective. We can see whether proteins are changed again after the translation, e.g. by phosphorylation or glycosylation. This means that we get a more detailed insight into the processes in the cell. This enables researchers to better research protein protein interactions and thus to better understand complex biological signal paths.
Proteomic is the next step on the way to more personalized medicine. In the future, research efforts can enable new biomarkers to better identify for diseases or therapeutic goals. In addition, proteomics can help us to better understand how medication acts on the body.
Research is still in the early stages, but there are already some very interesting studies. In this study, 36 people with different illnesses were examined before and after sports. The analyzes were extremely extensive and ranged from blood tests to proteomic and genetic analyzes. The researchers found that some proteins are suitable as a marker for later performance in endurance tests. They also found that people with insulin resistance react differently to sport. Until concrete treatment approaches can be derived from this, some research work is still necessary, but the results so far are extremely exciting.
At moleqlar analytics we use the mass spectrometry to measure proteins from cheek losing samples
Mass spectrometry
Definition
Mass spectrometry is an analysis technique that measures the mass load ratio (m/z) of molecules such as peptides, proteins and drug metabolites.
In the diagnostic area, mass spectrometry helps with the identification and quantification of unknown and well -known compounds as well as in evaluating your molecular structure and chemical composition, with better specificity and sensitivity than other methods. (Waddell Smith, 2013)
Revolution diagnostic tests
While mass spectrometry is widespread in basic research, the technology has also established itself for use in diagnostics in the past ten years. With the market launch of new generations of technologies, clinical laboratories use mass spectrometry for routine tests to improve molecular analyzes that can provide customers with faster test results compared to conventional assays.
Look at what we have discovered so far!
Our publications
Disabling Leading and Lagging Strand Histone Transmission Causes Loss of Parental Histones and Cell Viability,
Sciences Advances, 2025
Kollenstart et. al
Acute Multi-Level Response to Defective de Novo Chromatin Assembly in S-Phase,
Mol. Cell, 2024
Dreyer J., et. Al.
Backpain Exercise Therapy Remodels Human Epigenetic Profiles in Buccal and Human Peripheral Blood Mononuclear Cells,
Frontiers, 2024
Burny C., et. Al.
Symmetric inheritance of Parental Histones Govern's Epigenome Maintenance and Stem Cell Identity,
Nature Genetics, 2023,
Wenger A., et al.
Daxx Adds a de Novo H3.3K9Me3 Deposition Pathway to the Histone Chaperone Network,
Mol Cell. 2023
Carraro M, et al.
A Novel Proteomics Approach to Epigenetic Profiling of Circulating Nucleosomes.
Sci Rep. 2021; 11 (1): 7256.
Van den Ackerveken et. Al.
Proteomas Dynamics at Broken Replication Forks Reveal A Distinct ATM Directed Repair Response Suppressing DNA Double-Strand Break Ubiquitination.
Mol Cell. 2021; 81 (5): 1084-99 E6.
Nakamura K, et al.
Endotoxinemia accelerates atherosclerosis via Electrostatic Charge-Mediated Monocyte Adhesion.
Circulation. 2020.
Schumski a, et al.
Histone Modifications in Stem Cell Development and Their Clinical Implications.
Stem cell reports. 2020.
Voelker-Albert M., et al.
Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes.
Cell Rep. 2020.
Alabert C, et al.
New Approaches for Absolute Quantification of Stable Isotope-Labeled Peptides Standards for Targeted Proteomics Based on A UV Active Tag.
Proteomics. 2020.
Snatbaum K, et al.
Determining Histone H4 Acetylation Patterns in Human Peripheral Blood Mononuclear Cells Using Mass Spectrometry.
Clinical Mass Spectrometry. 2019.
Bux em, et al.
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